It’s no secret that per- and polyfluorinated alkyl substances (PFAS), also known as forever chemicals, are now well-established in the human body, with their presence detected in blood, umbilical cords and human milk. And while experts have linked PFAS exposure to health concerns like elevated cancer risks, endocrine disruption, developmental disruption and reduced immune system response, their impacts on the human brain remain relatively unknown.
However, a team led by researchers from the University at Buffalo has now identified 11 genes that could clear the way to better understanding how these chemicals affect brain tissue, and their level of neurotoxicity.
“Our findings indicate these genes may be markers to detect and monitor PFAS-induced neurotoxicity in the future,” G. Ekin Atilla-Gokcumen, lead co-corresponding author of the study and a chemistry professor at University at Buffalo, said in a statement.
The team exposed six types of PFAS to neuronal-like cells and lipids for a 24-hour period and found that these chemicals caused different expressions in 721 genes. These changes affected oxidative stress, protein synthesis, hypoxia signaling and amino acid metabolism, according to the study. They published their findings in the journal ACS Chemical Neuroscience.
Out of all the PFAS tested, perfluorooctanoic acid (PFOA) led to the widest spread changes in gene expression, affecting nearly 600 genes. By comparison, no other compound in the test affected expression of more than 147 genes. In July 2024, the U.S. Environmental Protection Agency (EPA) designated PFOA as a hazardous substance under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA).
In total, 11 genes were impacted to express in the same way after exposure to all six compounds. Some of these differently expressed genes were important for neuronal cell survival, the study found.
“Each of these 11 genes exhibited consistent regulation across all PFAS that we tested. This uniform response suggests that they may serve as promising markers for assessing PFAS exposure, but further research is needed to know how these genes respond to other types of PFAS,” Atilla-Gokcumen explained.
The study results may help scientists further determine how these accumulative chemicals impact human brains, but as of right now, there are no known, safe and effective methods for removing PFAS from the human body. Even determining the level of exposure to PFAS is complicated, with testing costing up to $500, Verywell Health reported. While PFAS blood testing costs are required to be covered by insurance in New Hampshire, coverage varies or may be unavailable in other states.
G. Ekin Atilla-Gokcumen’s lab found 11 genes that are consistently affected by PFAS exposure, either expressing more or less, regardless of the type of PFAS. Meredith Forrest Kulwicki / University at Buffalo
In February 2024, a separate study found that the cholesterol medication cholestyramine was effective at reducing PFAS levels in plasma. However, the study included a small sample of subjects, and the researchers determined that the medication was not suitable for widespread, long-term use for the purpose of lowering PFAS levels because of the risk of side effects, Medical Xpress reported.
For now, medical experts will continue researching how PFAS affect human health alongside ways to reduce the accumulation of these compounds in our bodies, including through alternative materials that could provide the same benefits, such as water- and stain-resistance, with lower risks to human health.
“If we understand why some PFAS are more harmful than others, we can prioritize phasing out the worst offenders while seeking safer substitutes,” Atilla-Gokcumen explained. “For example, alternatives like short-chain PFAS are being explored, as they tend to persist less in the environment and accumulate less in biological systems. However, their reduced persistence may come at the cost of effectiveness in certain applications, and there are concerns about potential unknown health effects that require further investigation. Further research is needed to ensure these substitutes are genuinely safer and effective for specific applications. This research is a major step towards achieving this goal.”
In the meantime, the EPA has recommended reducing exposure by checking PFAS levels in your public water supply or private well, installing filters that reduce PFAS in water and avoiding consumption of fish from PFAS-contaminated waterways.
Further, the Environmental Working Group (EWG) recommended reducing exposure to forever chemicals by limiting consumption of food in takeout packaging or paper board packaging, skipping non-stick cookware in favor of materials like stainless steel and cast iron, and avoiding clothing with aftermarket waterproofing or stain-resistant treatments.
The post Scientists Identify 11 Genes That Could Help Understand How PFAS Affects the Brain appeared first on EcoWatch.
https://www.ecowatch.com/pfas-brain-health.html
Thoreau wrote in Walden that “Time is but the stream I go a-fishing in,” which reminds us that life is short and nature fills it beautifully. What are you looking for that can’t be found during an afternoon in nature?
Earth911 inspirations. Post them, share your desire to help people think of the planet first, every day. Click the poster to get a larger image.
The post Earth911 Inspiration: Time Is but the Stream appeared first on Earth911.
https://earth911.com/inspire/earth911-inspiration-time-is-but-the-stream/
Green Living
Classic Sustainability In Your Ear: The Ocean River Institute’s Natural Lawn Challenge for Climate Action
Turn back the clock with this classic interview that will get you ready for Spring yard care planning. A lawn may be beautiful but it can take a heavy toll on the environment, accounting for between 30% and 60% of residential water use in the United States. Rob Moir, Ph.D., is president and executive director of the Ocean River Institute in Cambridge, Massachusetts. ORI works with residential lawn owners to heal damaged ecosystems by restoring coastal areas to lessen the destructive impacts of climate change. The benefits of a natural lawn reach far beyond reduced local water pollution, eliminating chemicals that can contribute to cancers, diabetes, Alzheimer’s disease, and other cellular diseases. Natural lawns are also better for local pollinators and store much more carbon than heavily fertilized lawns. If you considered removing your lawn to play a part in the battle against climate change, this interview may change your mind — a healthy lawn is a powerful carbon sink.
The Ocean River Institute is recruiting Massachusetts communities, town by town, to take a pledge to follow natural lawn practices in the Healthy Soils for Climate Restoration Challenge. You don’t need to live in Massachusetts to participate and learn about the alternatives to the traditional, chemical-intensive lawn practices that use Roundup, a source of glyphosates that kills soil-dwelling fungi and local pollinators, and fast-acting nitrogen fertilizers. You can learn more about the Ocean River Institute at www.oceanriver.org.
Rob has contributed many articles about climate change and the history of environmental change since this interview, including:
- Finding a Northwest Passage to the Sea
- Turning the Tide—How Land and Water Shape Our Climate Future
- Learning from Captain Scoresby’s Ten-gallon Fir-Cask
- Earth Savvy?
- Let the Ground Keep Falling Rainwater
- The Sultans of Swag Versus Looking at Clouds from Both Sides Now
- Subscribe to Sustainability in Your Ear on iTunes and Apple Podcasts.
- Follow Sustainability in Your Ear on Spreaker, iHeartRadio, or YouTube
Editor’s Note: This episode originally aired on May 30, 2022.
The post Classic Sustainability In Your Ear: The Ocean River Institute’s Natural Lawn Challenge for Climate Action appeared first on Earth911.
https://earth911.com/podcast/earth911-podcast-the-ocean-river-institutes-natural-lawn-challenge-for-climate-action/
Choosing your perfect gown can be one of the most exciting decisions for your special day, but for the eco fashionista, it can be a challenge to find a dress that fits your values and style — but these brands have exceptional sustainable wedding dresses you’ll swoon over!
Using earth-minded materials like hemp, cruelty-free peace silk, deadstock recycled fabrics and vintage lace, and producing consciously, either in small batches or handcrafting each individual piece made-to-order, the brands below meet high standards for transparency, ecological sustainability, and fair labor.
[For more sustainable wedding dresses, check out this guide to secondhand wedding dress sites!]
Note that the guide contains affiliate links. As always, we only feature brands that meet strict criteria for sustainability we love, that we think you’ll love too!
1. Christy Dawn
Dreamy dress brand Christy Dawn does not disappoint with their romantic bridal collection! Each piece is more swoon-worthy than the next.
Their three sustainable bridal gowns are made from regenerative silk charmeuse —sourced through BOMBYX, an innovative silk producer using best practices — and colored in a beautiful pearl silk with non-toxic dyes. Each dress is ethically cut and sewn by makers in Los Angeles earning living wages, as with the rest of Christy Dawn’s collections.
The Britta Dress and Fitzgerald Dress are 1920s inspired while the Athena Dress is a more modern (but equally romantic) option. All of these dresses are made-to-order with an estimated timeline of 4 weeks.
Conscious Qualities: Regenerative silk and organic non-toxic dyes, ethically made-to-order in Los Angeles
Price Range: $2,500 – $3,000
Size Range: XS – XL
2. Pure Magnolia
Blending the traditional with the modern, Pure Magnolia designs classic-inspired sustainable wedding dresses with contemporary touches. And each dress is made in their Canadian studio by seamstresses earning fair wages from eco-fabrics, such as organic cotton and hemp silk.
The brand sources recycled fabrics whenever possible as well, and recycles their scrap fabric through FABCYCLE.
Conscious Qualities: Eco-friendly fabrics, locally and fairly made, recycles scrap fabrics
Price Range: $845 – $3,300 CAD
Size Range: 0 – 28
3. Lost in Paris
Lost in Paris crafts each of their creatively designed bohemian-inspired gowns ethically in their Sydney, Australia studio. Unconventional yet undeniably striking, Lost in Paris’ dresses are made from vintage lace and cotton.
Investing in a dress from Lost in Paris is seamless — the brand offers at-home sample try-ons, offers train and sleeve adjustments on several styles, ships their dresses worldwide for free, and even accepts returns. Oh, and, if one of their ready-made sizes doesn’t work for you, you can get a dress designed to your measurements.
Conscious Qualities: Made-to-order model, uses vintage lace, locally made
Price Range: $950 – $3900 AUD
Size Range: XXS – XXL + custom sizing options
For More Slow Fashion Content:
4. Wear Your Love
Wear Your Love creates feminine, effortless dresses in their Northern California studio that are — in contrast to the majority of wedding dresses on the market — actually comfortable! The brand’s free-spirited designs are made with soft, earth-minded fabrics like organic cotton and each dress is made to order for each bride to their exact measurements.
There are also customizations available for each eco-friendly wedding dress such as train or no train, skirt or sleeve linings, back coverage, skirt style, and more.
Conscious Qualities: Eco-friendly fabrics, made-to-order model, locally and transparently made
Price Range: $680 – $1,700
Size Range: N/A; dresses are made to your measurements
5. Larimeloom
Based in Reggio Emilia, Italy, Larimeloom crafts exceptional custom-made dresses by hand in their atelier. The brand creates comfortable minimalist dresses from durable natural fabrics and colors them with natural or non-toxic dyes.
Larimeloom has also implemented zero waste design techniques, cutting their patterns strategically in order to minimize fabric waste.
Conscious Qualities: Made-to-order model, zero-waste designs, natural fabrics and dyes
Price Range: 650€ – 2,650€
Size Range: XS – XL
6. Sister Organics
Sourcing quality earth-friendly natural fabrics like organic hemp and cotton, Sister Organics creates classic, eco-friendly wedding dresses for UK-based brides.
Each dress is made to order in England, so you can select a pre-defined size, customize the length of a size, or get an entirely different dress made for your measurements.
Conscious Qualities: Eco-friendly fabrics, made-to-order model
Price Range: £125 – £390
Size Range: XXS – XXL + custom sizing
7. Indiebride London
Indiebride’s vintage-inspired sustainable wedding dresses are delicate and romantic yet free-spirited, offering a unique collection for the bride that wants to skip the conventional wedding gown and choose a piece that fits their individual style.
The brand’s conscious wedding dresses are handmade in London using majority natural fibers and can be altered or customized to your specifications.
Conscious Qualities: Made-to-order model, uses many natural fabrics, locally made
Price Range: £1,200 – £1,700
Size Range: 8 – 16 (UK sizes)
More Resources For Your Eco Wedding:
10 Secondhand Wedding Dress Sites for the Eco Bride
7 Ethical Lab-Grown Diamond Engagement and Wedding Rings
17 Brands with Conscious Dresses (great options for bridesmaid dresses in here!)
The post 7 Best Sustainable Wedding Dresses for Your Special Day appeared first on Conscious Life & Style.
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